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The electronegativity value of the sulfur atom (2.58) is similar to that of carbon (2.55) but lower than that of nitrogen (3.04), so doping with electron-accepting nitrogen atom imparted a higher positive charge density to neighboring sp 2 -bonded C atoms than S-doping

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2 Research has shown that rolling a dermaroller (with 192 needles, 200 m in length, and 70 m in diameter) over an area 15 times results in approximately 250 holes per cm 2 , thus the dermaroller used in this study possibly produced 703 holes approximately per cm 2

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This orchestrated immune response leads to a localized state of inflammation